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KMID : 1188320110050040432
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Gut and Liver
2011 Volume.5 No. 4 p.432 ~ p.436
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Increased Prevalence of Colorectal Neoplasia in Korean Patients with Sporadic Duodenal Adenomas: A Case-Control Study
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Chung Woo-Chul
Lee Bo-In
Roh Sang-Young
Kwak Jae-Wuk
Hwang Sun-Mee
Ko Yoon-Ho
Oh Jung-Hwan
Cho Hyun-Jung
Chae Hiun-Suk
Cho Young-Seok
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Abstract
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Background/Aims:Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects.
Methods:This retrospective case-control study used the databases of 3 teaching hospitals in Gyeonggi-do Province, South Korea. The colonoscopy findings of patients with sporadic duodenal adenomas were compared with those of age- and gender-matched healthy individuals who had undergone gastroduodenoscopies and colonoscopies during general screening examinations.
Results:Between 2001 and 2008, 45 patients were diagnosed endoscopically with sporadic duodenal adenomas; 26 (58%) of these patients received colonoscopies. Colorectal neoplasia (42% vs 21%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.1 to 7.4) and advanced colorectal adenoma (19% vs 3%; OR, 9.0; 95% CI, 1.6 to 50.0) were significantly more common in patients with sporadic duodenal adenomas than in healthy control subjects.
Conclusions:Compared with healthy individuals, patients with sporadic duodenal adenomas were at a significantly higher risk for developing colorectal neoplasia. Such at-risk patients should undergo routine screening colonoscopies.
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KEYWORD
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Duodenal neoplasms, Colorectal neoplasms, Colonoscopy, Endoscopy
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